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This denial of the bail was declared at Kaduna State High Court where the hearing of the case was held.
Gideon Kurada, the presiding judge said the accused El-Zakzaky and his wife have not shown any substantial medical evidence to grant them bail in their written application.
The judge ordered that the accused couple should remain in the custody of the Department of State Services (DSS) throughout the period of their trial.
The matter has been adjourned to January 22, 2019, for accelerated hearing.
El-Zakzaky and his wife have remained in the custody of the Department of State Services (DSS) since December 2015 following a clash between the IMN and soldiers of the Nigerian Army.
They were first arraigned on May 15, after two years of detention without a fair hearing.
The IMN leader is facing trial over allegations of culpable homicide, unlawful assembly, and disruption of public peace, among other charges.
The Shiite group regularly hold protest concerning the continued detention of their leader, Ibrahim El-Zakzaky who has been held by the Department of State Services (DSS) since December 2015, in spite of a court judgment ordering his release.
Many of the protests have been met with harsh treatment from the police and other security agencies that usually dispersed the crowds using tear gas and water cannons, and sometimes, live bullets.